VEGF-A/NRP1 STIMULATES GIPC1 AND SYX COMPLEX FORMATION TO PROMOTE RHOA ACTIVATION AND PROLIFERATION IN SKIN CANCER CELLS

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells

Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor.DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1.In the present study, the RNA interference of VEGF-A or NRP1 suppressed DJM-1 cell proliferation.Furthermore, the overexpression of the NRP1 wild Condoms type restored shNRP1-treated DJM-1 cell proliferation, where

read more